Researchers have developed a new 3D-printed hollow suppository designed to deliver cannabidiol (CBD) for epilepsy treatment. The device consists of an outer shell containing CBD and an inner spring structure, created using a combination of 3D printing technology and molding techniques.
The development addresses several limitations of traditional oral CBD medications, particularly the significant first-pass effect that reduces bioavailability. The hollow design allows for normal bodily functions while maintaining the medication’s position, making it especially suitable for children and patients who experience frequent bowel movements.
Image Credit: sciencedirect.com
Testing showed the suppository can release CBD slowly over a five-hour period and demonstrated both in vitro and in vivo safety. In rat models with epilepsy, the treatment showed positive results in reducing brain damage and inflammation, while also improving gut microbiota composition.
The research team utilized fused deposition modeling with thermoplastic urethane filaments to create the supporting spring structure. The outer shell was manufactured using a 3D-printed metal mold filled with a mixture of CBD, polyvinyl alcohol, and polyethylene glycol.
This development represents a new application of 3D printing technology in pharmaceutical manufacturing, specifically targeting patients who may have difficulty with oral medications. The researchers note this is the first instance of a 3D-printed drug-loaded suppository designed specifically for epilepsy treatment.
Source: sciencedirect.com
