by Georgetown University Medical Center
Changes in the structure of the double gel as χ3 (ordinate) is changed from 0 (demixed) to −1 (intertwined) (the intermediate steps, from left to right, are χ3 = −0.5, −0.9, −0.999). χ2 is shown in the abscissa, and the images refer to χ2 = 0.96875 ≈ 1 for the top row, and χ2 = 0.5 for the bottom row. The figures show two-dimensional slices of the whole gel. Credit: Proceedings of the National Academy of Sciences (2025). DOI: 10.1073/pnas.2423293122
A new study uncovers how fine-tuning the interactions between two distinct network-forming species within a soft gel enables programmable control over its structure and mechanical properties. The findings reveal a powerful framework for engineering next-generation soft materials with customizable behaviors, inspired by the complexity of biological tissues.
The study, titled "Inter-Species Interactions in Dual, Fibrous Gels Enable Control of Gel Structure and Rheology," is published in Proceedings of the National Academy of Sciences.
The study uses simulations to investigate how varying the strength and geometry of interactions between two colloidal species impacts network formation and rheological performance. By controlling separately interspecies stickiness and tendency to bundle, researchers discovered that tuning these inter-species interactions allows precise control over whether the networks that they form remain separate, overlap, or intertwine.
Key findings include:
- In general, reducing interspecies stickiness leads to double-network materials that are tougher. However, these materials are drastically different depending on the network architectures.
- Tendency to bundle causes networks to interpenetrate and reinforce one another, increasing toughness.
- The double-network architecture becomes itself a design principle to make materials that are more resilient or more tunable.
Crucially, the study shows that intertwined networks are reprogrammable—meaning gels can be reshaped post-formation by altering inter-species interactions. This discovery opens the door to materials that adapt their mechanics in response to environmental cues or external triggers.
Beyond providing new insights into soft matter physics, this work has broad implications for materials design in biomedicine, tissue engineering, soft robotics, and smart materials. Systems that mimic the cooperative behavior of biological networks could lead to more versatile and functional synthetic materials.
Implications for future research
Future research will explore how these principles can be experimentally realized in colloidal or polymeric systems and how inter-species interactions may be exploited to design materials that respond to light, temperature, or chemical changes, or that are instead very robust to those changes.
Understanding the rules that govern multi-network dynamics in soft materials could ultimately enable tailored solutions for applications requiring strength, flexibility, and responsiveness in one integrated material.
More information: Mauro L. Mugnai et al, Interspecies interactions in dual, fibrous gels enable control of gel structure and rheology, Proceedings of the National Academy of Sciences (2025). DOI: 10.1073/pnas.2423293122
Provided by Georgetown University Medical Center